PUBLICATIONS ET CONGRÈS

2014

CONGRES – AMERICAN COLLEGE OF RHEUMATOLOGY (ACR) ANNUAL MEETING 2014, 14-19 NOVEMBER, BOSTON, MA, USA – POSTER

 

Le management scientifique scientifique de Néovacs était présent lors du Congrès annuel de l’ACR avec un stand important.

 

 Booth ACR 1 Booth ACR 2 Booth ACR 3 Booth ACR 4

Présentation d’un poster:

 

Dissection of the Type I Interferon Response in Systemic Lupus Erythematosus : Serum IFNalpha Is Elevated in Lupus Nephritis and Correlates with IFN Score; IFNbeta Is Elevated in Mucocutaneous Disease. Julie Ducreux1, Fabien Colaone2, Severine Nieuwland1, Patrick Blanco3, Thierry Defrance4, Pierre Vandepapeliere2, Geraldine Grouard-Vogel2, Frederic A. Houssiau1 and Bernard R. Lauwerys1. 1Universite catholique de Louvain, Brussels, Belgium, NEOVACS SA, Paris, France, 3CHU Bordeaux, Bordeaux, France, 4INSERM, Lyon, France. 2014 ACR/ARHP Annual Meeting Abstract Supplement (pages S1–S1402) Page S710

 

 

2013


Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon a-kinoid.

Lauwerys BR, Hachulla E, Spertini F, Lazaro E, Jorgensen C, Mariette X, Haelterman E, Grouard-Vogel G, Fanget B, Dhellin O, Vandepapelière P, Houssiau FA. Arthritis Rheum, 2013, 65(2): 447-56. Pubmed


Active immunotherapy for chronic diseases.

Bachmann MF, Whitehead P. Vaccine, 2013, 31(14): 1777-84. Pubmed


Protection from articular damage by passive or active anti-TNFa immunotherapy in human-TNFa transgenic mice depends on anti-TNFa antibody levels.

Semerano L, Biton J, Delavallée L, Duvallet E, Assier E, Bessis N, Bernier E, Dhellin O, Grouard-Vogel G,Boissier MC. Clin Exp Immunol, 2013, 172(1): 54-62. Pubmed




2012


Modulation of anti-tumor necrosis factor alpha (TNF-a) antibody in mice immunized with TNF-a kinoid.

Assier E, Semerano L, Duvallet E, Delavallée L, Bernier E, Laborie M, Grouard-Vogel G, Larcier P, Bessis N, Boissier MC. Clin Vaccine Immunol, 2012,19(5): 699-703. Pubmed


CONGRES – Digestive Disease Week (DDW) 2012, 19-22 May, San Diego, CA, USA – Poster

Results of a Phase II, Randomized, Double Blind, Controlled Trial of the Efficacy of Active Therapeutic Immunization with TNF-Kinoid in Patients with Moderate to Severe Crohn’s Disease with Secondary Resistance to TNFα Antagonist. Dewit O, Hebuterne X, Dupas JL, Howaldt SM, Bures J, Schreiber S, Pace A, Klaus J, Bouhnik Y, Reinshagen M, Allez M, Hoffmann P, D’Haens GR, van Bodegraven AA, Stimac D, Goetz M, Kahi S, Vandepapeliere P, Colombel JF, Rutgeerts PJ, Vermeire S. Gastroenterology, 2012; Volume 142, Issue 5, (Suppl. 1): s567 – s568.


CONGRES – European League Against Rheumatism (EULAR) 2012, 06-09 June, Berlin, Germany – Poster

Active Therapeutic Immunization with TNF-Kinoid in Rheumatoid Arthritis Patients with Secondary Resistance to TNFα Antagonists is Safe and Immunogenic. Durez P, Miranda P, Toncheva A, Berman A, Rillo OL, Boutsen Y, Kehler T, Mociran E, Soto Saez L, Fautrel B, Mariette X, Sokalov P, Lucero E, Vlak T, Grazio S, Mastrovic K, Chirieac R, Grouard-Vogel G, Dhellin O, Ouary S, Fanget B, Vandepapelière P, Boissier MC. Annals of the Rheumatic Diseases, 2012; Volume 71 (Suppl. 3): 362. Abstract [FRI0152]


CONGRES – American College of Rheumatology (ACR) 2012, 09-14 November, Washington, DC, USA – Poster

Active Immunization with TNF-Kinoid in Rheumatoid Arthritis Patients with Secondary Resistance to Tumor Necrosis Factor-Alpha Antagonists Is Safe and Immunogenic. Durez P, Miranda P, Toncheva A, Berman Sr. A, Rillo OL, Boutsen Y, Kehler T, Mociran E, Saez L.S. Fautrel B, Mariette X, Solakov P, Lucero E, Vlak T, Grazio S, Mastrovic K, Chiriac R, Grouard-Vogel G, Dhellin O, Ouary S, Vandepapeliere P, Boissier MC. Arthritis & Rheumatism, 2012; Volume 64 (Suppl. 10): 479.


CONGRES – 25ème Congrès Français de Rhumatologie, 9-12 décembre, Paris

 



2011


Active immunisation of human interferon a transgenic mice with a human interferon a kinoid induces antibodies that neutralise interferon a in sera from patients with systemic lupus erythematosus

Mathian A, Amoura Z, Adam E, Colaone F, Hoekman MFM, Dhellin O, Vandepapelière P, Haroche J, Piette JC, Lebon P, Grouard-Vogel G. Ann Rheum Dis, 2011; 70(6): 1138–43. Pubmed


Interplay between TNF and regulatory T cells in a TNF-driven murine model of arthritis.

Biton J, Semerano L, Delavallée L, Lemeiter D, Laborie M, Grouard-Vogel G, Boissier MC, Bessis N. J Immunol, 2011; 186(7): 3899-910. Pubmed


CONGRES – European Crohn’s and Colitis Organisation (ECCO) 2011, 6th Congress on Inflammatory Bowel Diseases (IBD), February 24-26, Dublin, Ireland – Oral presentation

Phase I-II Safety, Immunogenicity and Clinical Results of TNFα-kinoid Immunotherapeutic Immunization In Crohn’s Disease Patients. Vandepapelière P, Malan F, Rogler G, van der Bijl A, Kruger F, Kruger D, Grouard-Vogel G, Dhellin O, Fanget B, Michetti P. Journal of Crohn’s and Colitis, 2011; Volume 5, Issue 1: s1-s192. Abstract [S416]


CONGRES – Lupus 2011, 8th European Lupus Meeting, April 6-9, Porto, Portugal- Poster

Therapeutic Active Immunization against IFNα in Patients with Lupus: a Phase I-II Study. Rashkov R, Hachulla E, Lazaro E, Jorgensen C, Amoura Z, Mariette X, Levy J, Grouard-Vogel G, Dhellin O, Vandepapelière P, Houssiau F. Lupus, 2011; Volume 204: 354-431 & 432-437. Abstract [P220]


CONGRES – DDW 2011, May 7-10, Chicago, Illinois, USA – Oral presentation

Safety, Immunogenicity and Clinical Phase I-II Results of TNFα-Kinoid Immunotherapeutic in Crohn’s Disease Patients. Vandepapeliere, P; Malan, F; Rogler, G; van der Bijl, A; Kruger, FC.; Kruger, DS.; Grouard-Vogel, G; Dhellin, O; Fanget, B; Michetti, P. Gastroenterology, 2011; Volume 140, Issue 5: s1: s123. Abstract [743]


CONGRES – EULAR 2011 May, 25-28 London, UK- Poster

Therapeutic Immunization against IFNα in Lupus Patients: a Phase I-II Clinical Study of IFN-Kinoid. Houssiau F, Rashkov R, Hachulla E, Lazaro E, Jorgensen C, Mariette X, Spertini F, Chizzolini C, Amoura Z, Levy J, Grouard-Vogel G, Dhellin O, Vandepapeliere P. Ann Rheum Dis 2011;70 (Suppl3):738 Abstract [AB0886]


CONGRES – INFLAMMATION 2011 June, 25-29 2011 Paris, France- Poster

Blocking IFNα in lupus patients through active therapeutic immunization: phase I-II clinical study of IFN-Kinoid. Vandepapelière P, Rashkov R, Hachulla E, Lazaro E, Jorgensen C, Mariette X, Spertini F, Chizzolini C, Grouard-Vogel G, Fanget B, Dhellin O, Houssiau F. Abstract [2474]


CONGRES – ACR 2011 75th Annual Scientific Meeting, November 5-9, 2011 Chicago, Illinois, USA – Oral presentation

Active Immunization Against IFN with IFN-Kinoid in SLE Patients Is Safe, Immunogenic and Induces Down-Regulation of IFN-Mediated Genes. Houssiau FA, Rashkov R, Hachulla E, Lazaro E, Jorgensen C, Spertini F, Mariette X, Grouard-Vogel G, Fanget B, Dhellin O, Lauwerys B, Vandepapeliere P. Arthritis & Rheumatism, 2011; Volume 63 (Suppl. 10): 2470.

 



2010


Kinoids: a family of immunogens for active anticytokine immunotherapy applied to autoimmune diseases and cancer.

Bizzini B, Drouet B, Zagury D, Abitbol M, Burny A, Boissier MC. Immunotherapy, 2010, 2(3): 347-65. Pubmed


CONGRES – ACR 2010 74th Annual Scientific Meeting of ACR, November 6-11, Atlanta, Georgia, USA – Poster

Differentiation and Activation of Regulatory T-Lymphocytes in a TNF-alpha Transgenic Model of Arthritis, and the Impact of Passive or Active Anti-TNF Therapies. Biton J, Semerano L, Delavallée L, Grouard-Vogel G, Lemeiter D, Boissier MC, Bessis N. Arthritis & Rheumatism , 2010; Volume 62: 10. Abstract [2236]


CONGRES – DDW 2010, 01 – 06 May 2010, New Orleans, USA – Poster

Active Therapeutic Immunization against TNF with a TNF-Kinoid in Crohn’s Disease Patients: A Phase 1-2 Study. Rogler G, Michetti PF, Kruger FC, van der Bijl A, Kruger DS, Malan F, Grouard-Vogel G, Dhellin O, Fanget B, Vandepapeliere P. Gastroenterology, 2010; Volume 138, Issue 5: s1-s517. Abstract [T1234]

 



2009


Active immunization to tumor necrosis factor-alpha is effective in treating chronic established inflammatory disease: a long-term study in a transgenic model of arthritis.

Delavallée L, Semerano L, Assier E, Vogel G, Vuagniaux G, Laborie M, Zagury D, Bessis N, Boissier MC. Arthritis ResTher 2009; 11(6): R195. Pubmed


IFNα kinoid vaccine-induced neutralizing antibodies prevent clinical manifestations in lupus flare murine model.

Zagury D, Le Buanec H, Mathain A, Larcier P, Burnett R, Amoura Z, Emilie D, Peltre G, Bensussan A, Bizzini B, Gallo RC, Koutouzov S. Proc Natl Acad Sci U S A, 2009, 106(13): 5294-9. Pubmed


CONGRES – European Association for Vision and Eye Research (EVER) 2009, September 30-October 3, Portoroz, Slovenia – Oral presentation

Anti-angiogenic Effect of VEGF-Kinoid Immunotherapy on Mice Experimental Choroidal Neovascularization. Bigot K,Provost A, Grouard-Vogel G, Zeghidi H, Bernier E, Adam-Buczkowski E, Zagury D, Abitbol M. Abstract [4352]


CONGRES – ACR 2009 73rd Annual Scientific Meeting of ACR, October 17-21, Philadelphia, PA, USA – Poster

Active Immunization with IFNα Kinoid® Induces Polyclonal Antibodies That Neutralize IFNα From Systemic Lupus Erythematosus Patients. Mathian A, Amoura Z, Adam E, Colaone F, Hoekman MFM, Vandepapelière P, Haroche J, Piette JC, Lebon P, Grouard-Vogel G. Arthritis & Rheumatism, 2009. Volume 60: 10 Abstract [1050]


CONGRES – ACR 2009 73rd Annual Scientific Meeting of ACR, October 17-21, Philadelphia, PA, USA – Poster

Active Immunization against VEGF Improves Joint Inflammation and Destruction in Collagen-Induced Arthritis. Assier E, Semerano L, Delavallée L, Grouard-Vogel G, Bernier E, Zagury D, Boissier MC. Arthritis & Rheumatism, 2009. Volume 60: 10 – Abstract [662]


CONGRES – Gastro UEGW/WCOG 2009, November 20 – 25, London, UK - Oral presentation

Therapeutic immunization against TNF with a TNF-Kinoid in Crohn’s disease patients is safe and induces anti-TNF. Benji P, Burger F, Kruger D, Rogler G, Michetti P, Kruger C, Grouard-Vogel G, Dhellin O, Fanget B, Vandepapelière P. Abstract [OP331]




2008


Early and long-lasting protection from arthritis in TNF{alpha} transgenic mice vaccinated against TNF{alpha}

Delavallée L. Le Buanec H, Bessis N, Assier E, Denys A, Bizzini B, Zagury D, Boissier MC. Ann Rheum Dis, 2008, 67(9): 1332-8. Pubmed


Les kinoïdes : Une nouvelle génération de vaccins thérapeutiques

Bensussan A, Bizzini B, Pouletty P, Gallo RC, Zagury D. Médicine Sciences, 2008, 24(3): 306-13. Pubmed




2007


Control of allergic reactions in mice by an active anti-murine IL-4 immunization.

Le Buanec H, Paturance S, Couillin I, Schnyder-Candrian S, Larcier P, Ryffel B, Bizzini B, Bensussan A, Burny A, Gallo RC, Zagury D, Peltre G. Vaccine, 2007, 25(41): 7206-16. Pubmed


VEGF kinoid vaccine, a therapeutic approach against tumor angiogenesis and metastases.

Rad FH, Le Buanec H, Paturance S, Larcier P, Genne P, Ryffel B, Bensussan A, Bizzini B, Gallo RC, Zagury D, Uzan G. Proc Natl Acad Sci U S A, 2007 104(8): 2837-42. Pubmed


CONGRES – Lupus 2007, 8th International Congress on SLE, May 23-27, Shanghai, China – Poster

Active Immunisation with IFNα Kinoid Prevents the Development of Systemic Lupus Erythematosus in an IFNα-induced Murine Model of Lupus Disease. Koutouzov S, Grouard-Vogel G, Larcier P, Le Buanec H, Mathian A, Emilie D, Zagury D. Lupus, 2007; Volume 16: 1-339. Abstract [CS1703]




2006


TNF {alpha} kinoid vaccination-induced neutralizing antibodies to TNF{alpha} protect mice from autologous TNF{alpha}-driven chronic and acute inflammation.

Le Buanec H, Delavallée L, Bessis N, Paturance S, Bizzini B, Gallo RC, Zagury D, Boissier MC. Proc Natl Acad Sci U S A, 2006 103(51): 19442-7. Pubmed




Archives


Anti-cytokine Ab immune therapy: present status and perspectives.

Zagury D, Gallo RC. DDT, 2004 9(2): 72-81. Pubmed


Active versus passive anti-cytokine antibody therapy against cytokine-associated chronic diseases.

Zagury D, Le Buanec H, Bizzini B, Burny A, Lewis G, Gallo RC. Cytokine Growth Factor Rev. 2003 14(2): 123-7. Pubmed


Non-toxic immunogens for therapeutic anticytokine vaccines

Zagury D, Le Buanec H, Bizzini B, Gallo RC. Idrugs, 2001 4(10): 1161-6. Pubmed


Toward a new generation of vaccines: the anti-cytokine therapeutic vaccines.

Zagury D, Burny A, Gallo RC. Proc Natl Acad Sci U S A, 2001 98(14): 8024-9. Pubmed


Active anti-interferon-alpha immunization: a European-Israeli, randomized, double-blind, placebo-controlled clinical trial in 242 HIV-1–infected patients (the EURIS study).

Gringeri A, Musicco M, Hermans P, Bentwich Z, Cusini M, Bergamasco A, Santagostino E, Burny A, Bizzini B, Zagury D. J Acquir Immune Defic Syndr Hum Retrovirol, 1999 20(4): 358-70. Pubmed